Viewing upcoming talks in: Cond Mat Seminars
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Physics and Astronomy Colloquia
Seeing with Atoms
Speaker: Professor Paul Dastoor (The university of Newcastle, Australia)
Imaging is the key to discovery in science and yet conventional microscopes can damage delicate materials and devices; altering the very structures that they are trying to see. However, the scanning helium microscope (SHeM) opens a new window on science; providing for the first time completely non-damaging imaging using beams of neutral helium atoms. This talk will explain the importance of microscopy in science and descibe how the development of the SHeM revolutionises the imaging of delicate materials (such as biological samples) and the potential for damage-free microscopy to impact society. The presentation will also highlight the importance of international collaboration in science and its role in the development of new technology.
On: April 26, 2019 From: 10h00 To: 11h00
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RSC Award LecturesRSC Harrison-Meldola Memorial Prize Lecture - Photoinduced Assembly of C-N Bonds
Speaker: Daniele Leonori (Manchester)
Photoinduced Assembly of C -N Bonds Dr Daniele Leonori School of Chemistry, University of Manchester, Manchester M13 9PL, UK daniele.leonori@manchester.ac.uk Nitrogen -containing compounds are a privileged class of molecules, which have applications in medicines, agrochemicals, dyes and materials. This relevance makes the construction of C –N bonds an extremely active area of research. Nitrogen -radicals are versa tile synthetic intermediates that can engage in a broad range of chemical reactions. 1 However, the difficulties associated with their generation have somewhat thwarted their use in synthetic chemistry. Development of Photoinduced Radical -Transposition Reactions We have developed a class of easy -to -make oximes and hyroxy -amides that upon photoredox oxidation enable access to iminyl and amidyl radicals. 2,3 These species have been used in radical transposition reactions for the site -selective functionaliza tion of unactivated sp 3-carbons. These strategies have been applied to the deconstruction –functionalization of complex steroids (radical ring -opening) 2 and to the preparation of unnatural aminoacids (1,5 -HAT) .3 Development of Photoinduced Aromatic C –H Ami nation Reactions Aminated aromatics are a widespread motif in high -value products. In general, these structures are assemble d by Pd or Cu -catalysed cross -couplings between aryl halides/organoboron and amines. We have developed an umpolung approach where electrophilic amidyl and aminyl radicals are generated by photoredox reduction of electron poor N-aryloxy -amides and -amines. 4,5 These radical specie s undergo highly selective addition to a broad range of electron rich aromatics thus enabling direct C – H amination. References 1. Review: S. Z. Zard Chem. Soc. Rev. 2008 , 37 , 1603. 2. Angew. Chem. Int. Ed. 2018 , 57 , 744. 3. Angew. Chem. Int. Ed. 2018 , 57 , 12495. 4. J. Am. Chem. Soc. 2016 , 138 , 8092. 5. Angew. Chem. Int. Ed. 2017 , 56 , 14948. Download PDFOn: May 1, 2019 From: 14h00 To: 15h00
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Cond Mat Seminars
Henry Legg
Speaker: Henry Legg (University of Cologne)
On: May 1, 2019 From: 13h00 To: 14h00
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ScotCHEM ColloquiaScotCHEM Industry Talk
Speaker: Matilda Bingham (Concept Life Sciences)
On: May 2, 2019 From: 14h00 To: 15h00
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EaStCHEM ColloquiaGuiding catalyst selectivity using biological architecture
Speaker: Amanda Jarvis (Edinburgh)
Guiding catalyst selectivity using biological architecture Dr Amanda Jarvis, University of Edinburgh Artificial metalloenzymes aim to combine the benefits of natural enzymes (selectivity, rate enhancement) with the scope of reactions provided by traditional transition metal chemistry (both reactions inspired by nature e.g. oxidations and reactions never s een in nature i.e. Pd cross -coupling reactions). 1 Proteins containing apolar cavities and tunnels have been utilised as scaffolds in which transition metal complexes can be introduced to build up catalysts that provide linear selectivities and improve subs trate turnover through enhancing substrate binding. 2 A number of different methods can be utilised to introduce the metal complex into the protein scaffold, including either introducing reactive amino acids (e.g. cysteine’s) which can subsequently be modi fied with a metal binding ligand, or directly introducing metal binding unnatural amino acids such as bipyridylalanine using amber stop codon suppression methodology. 3 In this talk, I will cover the work I have conducted towards developing artificial metal loenzymes using these methods for a range of synthetic challenges from reactions in water to C -H functionalisation.
1 Schwizer, F .; Okamoto, Y.; Heinisch, T.; Gu, Y.; Pellizzon i, M. M.; Lebrun, V.; Reuter, R.; Köhler, V.; Lewis, J. C.; Ward, T. R . Chem. Rev. 2018 , 118 , 142 . 2 Jarvis, A. G.; Obrecht, L.; Deuss, P. J.; Laan, W.; Gibson, E. K.; Wells, P. P.; Kamer, P. C. J. Angew. Chem., Int. Ed. 2017 , 56 , 13596. 3 Xie , J.; Liu, W.; Schultz, P. Angew. Chem. , Int. Ed. 2007 , 46 , 9239. Download PDFOn: May 8, 2019 From: 14h00 To: 15h00
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ScotCHEM ColloquiaBiocatalysis in drug discovery and drug development: Reimagining the manufacture of medicine at Novartis
Speaker: Radka Snajdrova (Novartis)
BIOCAT ALYSIS IN DRUG DISCOVERY AND DRUG DEVELOPMENT : REIMAGINING T HE MANUFACT URE OF MEDICINE AT NO V ART IS Dr. Radka Snajdrova Novartis Institute of Biomedical Research, GDC/Bioreactions, Basel, Switzerland. Biocatalysis has gained tremendous relevance in pharmaceutical industry over last decade. It has proven its utility in delivering green, atom efficient and economically viable routes, as well as frequently facilitating routes, inaccessible to traditional s y nt het i c chemistry, towards drug candidates and APIs. It is considered as one of the top priority technologies for drug substance manufactur ing at Novartis and is applied to the synthesis of APIs at all stages across the drug development cycle. This talk will cover seve ral aspects of biocatalysis in dr ug discovery and development, including example of development of an antimalarian drug, and the importance of en zy m e discovery and engineering. Download PDFOn: May 15, 2019 From: 14h00 To: 15h00
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