Viewing upcoming talks in: Cond Mat Seminars
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RSC Award LecturesInnovation in the Synthesis of Complex Pharmaceuticals
Speaker: Dr Martin Eastgate - RSC Organic Industrial Chemistry Award Winner (Bristol-Myers Squibb)
Innovation in the Synthesis of Complex Pharmaceuticals Martin D. Eastgate
Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, NJ, 08903 USA
Email: martin.eastgate@bms.com Modern pharmaceuticals are both increasingly complex 1 and increasingly diverse. Today’s clinical candidates often contain challenging stereochemistry, unique molecular architectures, and uncommon heterocyclic frameworks; they range from small molecules to natural products, peptides, oligonucleotides, antibody-drug conjugates and other modalities. Developing safe, scalable and efficient approaches to these molecules, in the context of increasingly short development timelines, requires an approach focused on maximizing impact through innovative chemical solutions – so called ‘disruptive innovations’. 2 However, increasing complexity brings challenges in the decision making process, impacting our ability to identify which chemical strategies will optimize sustainability. These decisions can be aided by predictive decision making tools, cognizant of potential environmental impact, and recent advances have begun to establish such methodologies. 3 This presentation will cover the synthetic strategies and chemical innovations developed to address several clinical candidates from the Bristol-Myers Squibb portfolio. Our approach 2 has led to the invention of several new synthetic approaches, 4 new chemical methods, 5-8 and new concepts in predictive data analytics. 3
[1] Li, J., Eastgate, M. D.; Org. Biomol. Chem., 2015, 13, 7164. [2] Eastgate, M. D., Schmidt, M. A., Fandrick, K. R., Nature Reviews: Chemistry, 2017, 1, 16. [3] Li, J., Borovika, A., Albrecht, A., Eastgate, M. D., ACS Green Chem. & Eng., 2018, 6, 1121; Li, J. and Eastgate, M. D., RSC React. Chem. & Eng., DOI: 10.1039/c9re00019d; Borovika, A. et al., ChemRxiv DOI 10.26434/chemrxiv.7594646.v1. [4] Schmidt, M., Simmons, E. M., Wei, C. S., Li, H., Eastgate, M. D., J. Org. Chem., 2018, 83, 3928. [5] Knouse, K. W., et al, Science 2018, 361, 1234 [6] Foo, K., Sella, E., Thome, I., Eastgate, M. D., Baran, P. S., J. Am. Chem. Soc., 2014, 136, 5279. [8] Kheirabadi, M., Creech, G., Nirschel, D., Qiao, J., Leahy, D., Boy, K., Carter, P., and Eastgate, M. D., J. Org. Chem., 2018, 83, 4323. Download PDFOn: January 22, 2020 From: 14h00 To: 15h00
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Cond Mat Seminars
4 months talks by 1st year PhD students
Speaker: Olivia Armitage, Izidor Benedicic, Brendan Edwards, Thibaut Lacroix, Liam Trzaska, Andela Zivanovic ()
Talks given by first year PhD students in condensed matter outlining their planned work.On: January 29, 2020 From: 12h00 To: 14h00
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Physics and Astronomy ColloquiaStephen Smartt- TBC
Speaker: Prof Stephen Smartt (University of Belfast)
On: January 31, 2020 From: 10h00 To: 11h00
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EaStCHEM ColloquiaDynamic behaviour and catalysis in metal-organic frameworks (MOFs)
Speaker: Prof Lee Brammer (Sheffield)
Dynamic behaviour and catalysis in metal -organic frameworks (MOFs)
The seminar will focus on two areas of interest in my group that relate to the class of crystalline porous materials known as metal -organic frameworks (MOFs). In the first part of the lecture I will discuss strategies for using MOFs to embed catalytic cen tres to provide active, well -characterised single -site heterogeneous catalysts. In the second part I will discuss flexibility and guest -responsive dynamic behaviour in a MOF system that we have recently developed.
References Chem. Soc. Rev. 2017 , 46 , 5444 -5462. Nat. Chem. 2017 , 9, 882 -889. Chem. Sci. 2016 , 7, 2037 -2050 Angew. Chem. Int. Ed. 2018 , 57, 4532 -4537. Inorg. Chem. 2018 , 57 , 1171 -1183. Download PDFOn: February 5, 2020 From: 14h00 To: 15h00
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EaStCHEM Colloquia
Photoelectron spectroscopy of materials: from fundamental insights to technological applications
Speaker: Dr David Payne (Imperial College London)
On: February 12, 2020 From: 14h00 To: 15h00
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Cond Mat Seminars
Stephen McVitie
Speaker: Stephen McVitie (University of Glasgow)
On: February 12, 2020 From: 12h00 To: 13h00
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