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Viewing upcoming talks containing the keyword: 3
ScotCHEM Industry Talk - Biology needs organic chemistry; Concept Life Sciences’ chemistry for ADC, PROTAC, kinase and nucleotide research.
Speaker: Matilda Bingham (Concept Life Sciences)
Concept Life Sciences is a science led business focused on delivering a comprehensive platform of services of which organic synthesis forms a critical part. Our chemists work in a collaborative way with colleagues in biology, DMPK (distribution, metabolism and pharmacokinetics), bioanalytics and toxicology to design chemistry to apply to novel small molecules, biomolecules, peptide conjugates and hybrid molecules as part of wider research programmes designed to answer critical questions about biological systems.
In this talk we will discuss some of our work in the areas of antibody drug conjugates (ADCs), protein targeting chimeras (PROTACs), kinase inhibitors and nucleotides.
On: May 2, 2019 From: 14h00 To: 15h00View talk
Speaker: Amanda Jarvis (Edinburgh)
Guiding catalyst selectivity using biological architecture Dr Amanda Jarvis, University of Edinburgh Artificial metalloenzymes aim to combine the benefits of natural enzymes (selectivity, rate enhancement) with the scope of reactions provided by traditional transition metal chemistry (both reactions inspired by nature e.g. oxidations and reactions never s een in nature i.e. Pd cross -coupling reactions). 1 Proteins containing apolar cavities and tunnels have been utilised as scaffolds in which transition metal complexes can be introduced to build up catalysts that provide linear selectivities and improve subs trate turnover through enhancing substrate binding. 2 A number of different methods can be utilised to introduce the metal complex into the protein scaffold, including either introducing reactive amino acids (e.g. cysteine’s) which can subsequently be modi fied with a metal binding ligand, or directly introducing metal binding unnatural amino acids such as bipyridylalanine using amber stop codon suppression methodology. 3 In this talk, I will cover the work I have conducted towards developing artificial metal loenzymes using these methods for a range of synthetic challenges from reactions in water to C -H functionalisation.
1 Schwizer, F .; Okamoto, Y.; Heinisch, T.; Gu, Y.; Pellizzon i, M. M.; Lebrun, V.; Reuter, R.; Köhler, V.; Lewis, J. C.; Ward, T. R . Chem. Rev. 2018 , 118 , 142 . 2 Jarvis, A. G.; Obrecht, L.; Deuss, P. J.; Laan, W.; Gibson, E. K.; Wells, P. P.; Kamer, P. C. J. Angew. Chem., Int. Ed. 2017 , 56 , 13596. 3 Xie , J.; Liu, W.; Schultz, P. Angew. Chem. , Int. Ed. 2007 , 46 , 9239. Download PDF
On: May 8, 2019 From: 14h00 To: 15h00View talk
Biocatalysis in drug discovery and drug development: Reimagining the manufacture of medicine at Novartis
Speaker: Radka Snajdrova (Novartis)
BIOCAT ALYSIS IN DRUG DISCOVERY AND DRUG DEVELOPMENT : REIMAGINING T HE MANUFACT URE OF MEDICINE AT NO V ART IS Dr. Radka Snajdrova Novartis Institute of Biomedical Research, GDC/Bioreactions, Basel, Switzerland. Biocatalysis has gained tremendous relevance in pharmaceutical industry over last decade. It has proven its utility in delivering green, atom efficient and economically viable routes, as well as frequently facilitating routes, inaccessible to traditional s y nt het i c chemistry, towards drug candidates and APIs. It is considered as one of the top priority technologies for drug substance manufactur ing at Novartis and is applied to the synthesis of APIs at all stages across the drug development cycle. This talk will cover seve ral aspects of biocatalysis in dr ug discovery and development, including example of development of an antimalarian drug, and the importance of en zy m e discovery and engineering. Download PDF
On: May 15, 2019 From: 15h00 To: 16h00View talk
Speaker: Stuart Cantrill (Nature)
This talk will take a behind -the -scenes look at Nature Chemistry’s editorial processes, as well as providing some guidance on how to write a paper, how to write an abstract and some DOs and DON'Ts when it comes to titles and graphical abstracts – there will also be some advice on how best to appeal an editorial decision. In addition, there will be a broader consideration of peer review in general, the wider chemistry publishing landscape and also other aspects related to scientific publishing including metrics (impact factor, altmetrics, and so on) and the use of social media. Download PDF
On: May 21, 2019 From: 14h00 To: 15h00View talk
Quantum decoherence in coupled optical systems: modelling, and implications for solar energy harvesting
Speaker: Brendon Lovett (University of St Andrews)
Optically active nanostructures sharing a common electromagnetic environment experience field-mediated interactions, which may in turn influence how they absorb and emit light. Interestingly, this opens possibilities for engineering their dissipative behaviour through quantum interference.Re-emission of absorbed photons is an important factor in the Shockley Queisser limit on the efficiency of conventional photovoltaic devices. Quantum interference between two optical dipoles enables states enjoying dark-state protection, where optical excitations are stored until their energy has been converted into a more useful longer-lived form. Going beyond a previous proposal for idealised highly symmetric systems , I here show that this concept equally applies to wide classes of non-identical organic molecular dimers, or coupled rings of several dipoles [2,3], each of which can outperform the idealised case under realistic constraints.I will go on to discuss more generally two qubits strongly coupled to an environment. Here, we find that simple “time-local” descriptions of the open system’s behaviour fail, since the environment can maintain a memory of its interaction with the system. I will therefore briefly describe our new, ultra-efficient exact method of describing quantum dynamics under these conditions , and discuss an application to energy transfer. C. Creatore, M. A. Parker, S. Emmott, and A.W. Chin, Phys. Rev. Lett. 111 253601 (2013). A. Fruchtman, R Gomez-Bombarelli, B. W. Lovett, and E. M. Gauger, Phys. Rev. Lett. 117 203603 (2016). K. D. B. Higgins, B. W. Lovett and E. M. Gauger, J. Phys. Chem. C 121, 20714 (2017). A. Strathearn, P. Kirton, D. Kilda, J. Keeling and B. W. Lovett, Nature Communications 9 3322 (2018)
On: May 21, 2019 From: 13h00 To: 14h00View talk
Speaker: Jennifer Garden (Edinburgh)
Replacing petroleum-derived feedstocks with renewable sources is an attractive method to improve the sustainability of chemical production, with desired targets ranging from small to macro-molecules. These processes usually require the presence of a catalyst; some of the most efficient are homogeneous metal complexes. This presentation will discuss the development of homo- and hetero-metallic catalysts for upcycling CO2 into polycarbonates or cyclic carbonates, and lactide into poly(lactic acid).
In the reaction between CO2 and epoxides, catalyst design can direct product formation towards polycarbonates or cyclic carbonates. A series of heterobimetallic Mg/Zn complexes based on a macrocyclic ligand have been developed which give >99% selectivity for polycarbonates. These synergic heterobimetallic complexes display catalytic activities up to 40 times higher than the homobimetallic analogues, either alone or in combination (TOF <8800 h-1). We have also developed a series of monometallic phenoxyimine Fe(III)-chloride complexes which exploit enhanced ligand flexibility to promote cyclic carbonate formation (>99% selectivity). Notably, these robust and selective Fe(III) catalysts are tolerant to air and water, and successfully convert the internal epoxide, cyclohexene oxide, to cyclohexene carbonate.
The ring-opening polymerisation of lactide is a useful means to prepare biodegradable materials with well controlled polymer architectures and bespoke material properties. This presentation will describe a series of highly active Al-chloride catalysts based on a functionalisable salen ligand. Incorporating Lewis basic NEt2 groups into the ligand scaffold not only improves the initiation efficiency but also avoids the need for a Lewis basic co-catalyst and excess epoxide. Studies of our amino-substituted catalysts reveal that the formation of a hexacoordinate aluminate species may hinder rather than enhance the catalyst activity.
On: May 22, 2019 From: 14h00 To: 15h00View talk