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Viewing upcoming talks containing the keyword: 19
Speaker: Veronique Gouverneur (Oxford)
The impact of fluorine chemistry in the life sciences is enormous. As many as 30−40% of agrochemicals and 20% of pharmaceuticals on the market are estimated to contain fluorine. 19F - and 18F -labelled compounds are also finding increasing applications in i maging such as Magnetic Resonance Imaging [MRI] or Positron Emission Tomography [PET]. As a result, there is an increasing demand for facile methods allowing for the fluorination using 19F and the radioisotope 18F of a large variety of structurally complex and functionalised small molecules as well as biologics. This lecture will discuss our recent contributions to the field of late stage fluorination with an emphasis on the challenges associated with the use of alkali metal fluoride, and how these can be o vercome. Download PDF
On: March 11, 2019 From: 14h00 To: 15h00View talk
Speaker: Timothy Noel (Eindhoven)
Innovation in synthetic methodology through use of flow T i m o t h y N o ë l E i n d h o v e n U n i v e r s i t y o f T e c h n o l o g y , D e p a r t m e n t o f C h e m i c a l E n g i n e e r i n g & C h e m i s t r y , M i c r o F l o w C h e m i s t r y & S y n t h e t i c M e t h o d o l o g y , E i n d h o v e n , T h e N e t h e r l a n d s E-m a i l : t . n o e l @ t u e . n l ; w e b s i t e : w w w . N o e l R e s e a r c h G r o u p . c o m ; T w i t t e r : @ N o e l G r o u p T U E
Until recently, many reactions have been exclusively performed in co nventional batch LabWare. With the advent of microreactor technology, significant effort has been devoted to develop a wide variety of continuous -flow techniques to facilitate organic synthesis. Microreactor technology offers several advantages compared to traditional batch reactors, such as, enhanced heat - and mass -transfer, improved irradiation, safety of operation and the possibility to integrate several reaction steps and subsequent separations in a single streamlined process. 1 My group has taken a grea t interest in assisting chemists by developing automated and flow -based reaction technologies capable of reducing manual labor, increasing the reproducibility of the results and accelerating reaction discovery. In this presentation, we will give an overvie w of our synthetic methodology development, exemplified by photoredox catalysis 2, C –H activation chemistry 3 and electrochemistry 4 and how these synthetic methods were impacted by continuous -flow microreactor technology. Furthermore, we will discuss the dev eloped technology and reaction models in detail.
1. (a) H. P. L. Gemoets, Y. Su, M. Shang, V. Hessel, R. Luque, T. Noel, Chem. Soc. Rev. 2016 , 45 , 83 -117. (b) D. Cambie, C. Bottecchia, N. J. W. Straathof, V. Hessel, T. Noel, Chem. Rev. 2016 , 116 , 10276 -10341.
2. (a) X. -J. Wei, W. Boon, V. Hessel, T. Noel, ACS Catal. 2017 , 7, 7136 -7140. (b) C. Bottecchia, M. Rubens, S. Gunnoo, V. Hessel, A. Madder, T. Noel, Angew. Chem. Int. Ed. 2017 , 56 , 12701 -12707. (c) D. Cambie, F. Zhao, V. Hessel, M. G. Debije, T. Noel, Angew. Chem. Int. Ed. 2017 , 56 , 1050 -1054. (d) N. J. W. Straathof, S. E. Cramer, V. Hessel, T. Noel, Angew. Chem. Int. Ed. 2016 , 55 , 15549 -15553.
3. (a) G. Laudadio, S. Govaerts, Y. Wang, D. Ravelli, H. F. Koolman, M. Fagnoni, S. W. Djuric, T. Noel, Angew. Chem. Int. Ed. 2018 , 57 , 4078 -4082.. (b) H. P. L. Gemoets, G. Laudadio, K. Verstraete, V. Hessel, T. Noel, Angew. Chem. Int. Ed. 2017 , 56 , 7161 -7165. (c) U. K. Sharma, H. P. L. Gemoets, F. Schoeder, T. Noel, E Van der Eycken, ACS Catal. 2017 , 7, 3818 -3823.
4. (a) G. Laudadio, W. De Smet, L. Struik, Y. Cao, T. Noel, J. Flow Chem. 2018 , 8, 157 -165. (b) G. Laudadio, N. J. W. Straathof, M. D. Lanting, B. Knoops, V. Hessel, T. Noel, Green Chem. 2017 , 19 , 4061 -4066.
med and being readable. Download PDF
On: March 13, 2019 From: 14h00 To: 15h00View talk
Speaker: Muriel Hissler (Rennes)
Advances in P - based Molecular Materials for Opto -electronic Application Pr Muriel HISSLER Université de Rennes1, CNRS, UMR 6226, Institut des Sciences Chimiques de Rennes, Campus de Beaulieu, 35042 Rennes, France Since the pioneering work of Shirakawa , Heeger and McDiarmid in the 1970’s, the interest for organic -conjugated systems has grown tremendously. Indeed organic materials offer the possibility to process light -weight, flexible electronic devices, however, they have to satisfy a large number of technical requirements in order to be stable and efficient in the device. The insertion of a heteroelement into the backbone has appeared as an appealing way to tune the properties of the materials. Heterocycles like thiophene , pyrrole, and their derivatives are now widely used to modify chemical and physical properties of -conjugated systems. Interestingly, while organophosphorus derivatives have been investigated for decades, their insertion into devices has only been achiev ed recently. The high reactivity and toxicity of many P -derivatives is one of the reason but the ability of chemists to stabilize and protect the P -atom allowed the introduction of organophosphorus derivatives into opto -electronic devices. Here, we will re port on phosphorus based molecular materials: their synthesis, their unique properties useful for organic electronic materials, and the devices that they have been incorporated in so far. For example, we have shown that phosphorus heterocycles (phospholes, phosphetes, phosphepines…) are appealing building blocks for the construction of - conjugated systems. Effectively, the reactivity of the P -center allows a straightforward HOMO - LUMO gap tuning as evidence by photophysical and electrochemical studies. The coordination ability of the P - center allows unprecedented coordination -driven assembly of -systems onto transition metals. All these physical properties make phosphorus heterocycles valuable building blocks for the development of material for optoelectron ic applications.
Keywords: Heterochemistry, Phosphorus heterocycles, Aromaticity, -systems, Organic Optoelectronics References:  D. J oly, D.; P. A. Bouit, M. Hissler, J. Mater. Chem. C 2016 , 4, 3686.  M. P. Duffy, W. Delaunay, P.A. Bouit, M. Hissler, Chem. Soc. Rev. 2016 , 45, 5296. Optoelectronic Applications OLEDs, Solar cells, OFETs… P Oligomers, Polymers, Polycycles … Organophosphorus -conjugated systems P -chemistry / Heterochemistry / Organometallics Download PDF
On: March 20, 2019 From: 14h00 To: 15h00View talk
Speaker: Ian Manners (University of Victoria, British Columbia, Canada and the University of Bristol, UK)
Molecular, and more recently, macromolecular synthesis has evolved to an advanced state allowing the creation of remarkably complex organic molecules and well -defined polymers with typical dimensions from 0.5 nm - 10 nm. In contrast, the ability to prepare materials in the 10 nm – 100 micron size regime with controlled shape, dimensions, and structural hierarchy i s still in its relative infancy and currently remains the virtually exclusive domain of biology. In this talk recent developments concerning a promising “seeded growth” route to well -defined 1D and 2D nano - and microparticles termed “living” crystalliza tion -driven self -assembly (CDSA), will be described. Living CDSA can be regarded as a type of “living supramolecular polymerization” that is analogous to living covalent (e.g. anion initiated) polymerizations of molecular monomers but on a much longer leng th scale (typically, 10 nm – 5 microns). Living CDSA also shows analogies to biological “nucleation -elongation” processes such as amyloid fiber growth . The building blocks or “monomers” used for living CDSA consist of a rapidly expanding range of crystal lizable block copolymers, homopolymers with charged termini, or planar p-stacking molecules with a wide variety of chemistries. The seeds used as “initiators” for living CDSA are usually prepared from preformed polydisperse 1D or 2D micelles by sonication. As a useful alternative, they can be formed in situ in solution by thermal treatment and/or by using conditions of controlled solvency. The “ in situ ” method is termed 1D or 2D “self -seeding” and has its origins in early work on the growth of polymer singl e crystals . Recent results indicate that through combination with the polymerization -induced self - assembly (PISA) method, living CDSA is scalable and therefore offers the potential to prepare uniform samples of 1D and 2D nanoparticles and hierarchical ma terials with potential applications in areas such as optoelectronics, catalysis, and biomedicine. Recent examples of work by our group and our collaborators, and also by other workers in the field, will be discussed . Selected Recent References: Scienc e 2015, 347, 1329; Science 2016 , 352, 697; Nature Chem. , 2017 , 9, 785; Nature Mater. 2017 , 16 , 481; Nature Comm. , 2017 , 8: 15909; ACS Nano 2017 , 11 , 9162; Nature Comm. 2017 , 8: 426. Science 2018 , 360 , 897. Download PDF
On: April 1, 2019 From: 16h00 To: 17h00View talk
Speaker: Leticia Gonzalez (Vienna)
Excited states and ultrafast chemical dynamics on the computer
Leticia González Department of Theoretical Chemistry, University of Vienna, Währinger Strasse 17, 1090 Vienna, Austria,
When molecules are irradiated by light, they are electronically excited, undergoing photophysical and photochemical processes. These processes mean that the molecule will explore different regions of the excited potential energy surfaces, which nowadays can be mapped with different theoretical methods, from the stationary and dynamical point of view. Due to the often pseudo-degeneracy of states and the involvement of potential surfaces of same or different multiplicity that can cross, breaking the Born-Oppenheimer approximation, the calculation of electronic excited states has not yet reached the maturity and accuracy which is golden standard in the electronic ground state. In this lecture, the current efforts of our group on understanding the behaviour of molecules under light irradiation and its dynamics will be reported. Particular emphasis will be made on the recent advancements made using SHARC , our home-made code for the studying ultrafast excited state dynamics.
 S. Mai, P. Marquetand, L. González, Nonadiabatic dynamics: The SHARC approach Wiley Interdiscip. Rev. Comput. Mol. Sci. 8, e1370, (2018) Download PDF
On: April 3, 2019 From: 15h30 To: 16h30View talk
Speaker: Cristina Nevado (Zurich)
Complex Natural Products as Tool s to Explore Cancer Progression and Cell Motility Small molecules that target the actin cytoskeleton have long been recognized as va luable molecular probes and pharmaceutical agents. We have investigated the cellular targets of iriomoteolide -3a and a collection of related macrolide analogues. A new approach for their synthesis has enabled scaffold -diversification and solved the supply problem. Structure -activity relationships suggest that actin is one of iriomoteolides' primary cellular targets – according to their inhibition of cell migration, induction of morphological changes, reversible cytoplasmic retraction and reduction of F -acti n fibers in a time and dose dependent manner. These results showcase iriomoteolides as novel and easily tunable chemical probes for the in vitro study of actin dynamics in the context of cell motility processes including cell invasion and division. Download PDF
On: April 10, 2019 From: 15h30 To: 16h30View talk