Design, evolution and applications of protein cages - Joint EaStCHEM/BSRC Colloquium

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Don Hilvert
Many proteins spontaneously self -assemble into regular, shell -like, polyhedral structures. Protein cage s are useful — in na ture and in the laboratory — as molecular containers for diverse cargo molecules, including proteins, nucleic acids, metal nanoparticles, quantum dots, and low molecular weight drugs. They can consequently serve as delivery vehicles, bioimaging agents, reac tion vessels, and templates for the controlled synthesis of novel materials. Most ambitiously, self - assembly of hierarchically ordered supramolecular structures may serve as catalytic nanoreactors for short metabolic sequences. In this lecture , strategies for designing new protein containers, optimizing them by directed evolution and characterizing their structures and properties will be discussed. These efforts may provide practical routes to non -viral encapsulation systems for diverse applications in th e test tube and in living cells. Download PDF

  • Venue

    Theatre C, Purdie

  • Venue Info

  • Date

    May 16, 2018

  • Time

    From: 15h30 To: 16h30

  • Sponsor

    University of St Andrews
    The oldest university in Scotland, with international renown for both research and education of undergraduates and postgraduates.

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