From Bacterial to Biomimetic Magnetosomes for Nanomedicine and Nanotechnology (Video Conference from Edinburgh)
Main list: EaStCHEM Colloquia
Magnetic nanoparticles (MNPs) have many applications, particularly over a range of emerging biomedical diagnostic and therapeutic nanomedicine such as targeted and hyperthermic drug delivery and diagnostics such as MRI contrast agents. Similarly they have high value in nanotechnologies such as ultra high-density data storage.
MNPs often require a mono-disperse size and shape distribution to ensure their magnetic behaviour is consistent, which can require chemical synthesis under harsh conditions.
Magnet bacteria synthesis nanoparticles of magnetite within lipid vesicles (known as magnetosomes) within their cells. These precise magnetosomes can be extracted and used for various biomedical applications, but their properties are restricted to the natural form, limiting their applications.
In this talk I will show 1) how we can alter the magnetosomes in vivo to produce enhanced MNPs for a range of biomedicine, 2) Utilise key biomineralisation proteins from the bacteria in vitro as an additive to control the of MNPs in a “green” chemical precipitation. 3) Utilise novel methods of developing new protein additives to control the shape of MNPs via green synthesis. 4) utlise these proteins on surfaces to form precise arrays of mono-dispersed MNPs with potential application in nanotechnology and 5) Show we can biomimic the magnetosome itself to produce a completely artificial magnetosomes and hybrid magnetovesicle materials for biomedical applications.
Video Conference, Theatre C, Purdie, University of St. Andrews, St. Andrews, Fife, Scotland, UK
February 3, 2016
From: 16h00 To: 17h00
The University of Edinburgh
Promoting excellence in teaching and research.